Analysis on the Correlation of Fungus Extracts Allergen and the Components of Aspergillus Fumigatus sIgE Sensitization in Respiratory Allergic Diseases Patients in Southern China

W. Luo1, Z. Wu2, H. Hu1, B. Sun1;

Author address: 

1First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 2First Affiliated Hospital of Guangzhou Medical University, guangzhou, China.

Abstract: 

Objective: Aspergillus fumigatus is the most common airborne mycotic allergen, there is still a lack of detailed studies investigating allergy caused by various mycotic allergen crude extracts and sIgE allergy and their correlation with Aspergillus fumigatus components. Therefore, we enrolled patients with allergic respiratory diseases in Southern China and to carry out a pilot analysis. Method: We collected 4033 patients with respiratory diseases that undergone Aspergillus fumigatus allergen sIgE tests, and randomly selected A total of 145 patients with Aspergillus fumigatus-positive adults and 50 patients with Aspergillus fumigatus-negative adults to simultaneously detected seven mycotic allergens including Aspergillus fumigatus, Penicillium chrysogenum, Cladosporium herbarum, Mucor racemosus, Candida albicans, Alternaria alternate and Helminthosporium halodes, and total IgE and to analyse their correlation. Among the 195 patients, 72 Aspergillus fumigatus-positive patients and 7 Aspergillus fumigatus-negative patients were randomly chosen for detection of Aspergillus fumigatus components Asp f 1, Asp f 2, Asp f 3, Asp f 4 and Asp f 6. Result: In 4033 patients, 7.30% were positive for Aspergillus fumigatus allergen sIgE, with an average sIgE level of 1.10 (0.54-3.79) kU/L. the majority of fungus-positive incidents were Aspergillus fumigatus , accounting for 23.3% of all Fungus-positive cases.Each Fungus tested had high positivity rate in combined sIgE sensitization with Aspergillus fumigatus (84.6%~100%), Aspergillus fumigatus also showed correlation with all other Fungus (0.51~0.82, P<0.05); The correlation between total IgE level and each fungus was mostly medium-strong (0.45-0.69, P<0.05);85% of the patients showed positive results for 2 or more Aspergillus fumigatus components, Each Aspergillus fumigatus component was positively correlated with the total IgE (0.51-0.75, all P<0.01). The correlation between Aspergillus fumigatus and Asp f 2 was the strongest (r=0.73, P<0.01). Conclusion: We shows that the complicated relationship among Aspergillus fumigatus, its components and other mycotic allergens. and our study has some reference value to local doctors in the diagnosis of adult mycotic allergy, especially Aspergillus fumigatus sensitization.

2018

abstract No: 

A1276 / P1017

Full conference title: 

The American Thoracic Society Conference 2018
    • ATS 2018