Analysis on Correlation Between SIgE to Carbohydrate Cross-Reactive Determinants and Plant-Related Allergens SIgE

W. Luo1, B. Sun2, Z. Wu3;

Author address: 

1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Diseases, First Affliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China, 2First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 3First Affiliated Hospital of Guangzhou Medical University, guangzhou, China.

Abstract: 

Purpose To detect the serum IgE to carbohydrate cross-reactive determinants(CCD) and plant-related allergens sIgE, and analyse their correlation evaluating the characteristic of cross reaction, occuring in both CCD and plant-related allergens ,for providing some reference value to the diagnosis of plant-related allergens sensitization.Method We collected 94 patients having a history of plant-related allergen sensitization to detect 21 allergens, including CCD, peanut (f13), soybean (f14), ragweed (w1), mugwort (w6), trees-mixed (poplar/willow/elm, ts4), humulus(u80), mites-mixed:(house dust mites/flour mites, ds1), house dust (h1), cockroach (i6), dog epithelium (e2), cat hair (e1), moulds-mixed (penicillium/aspergillus/cladosporium/alternaria, ms1), egg white (f1), milk (f2) and crab (f23), shrimp (f24), fished-mixed 1(cod/lobster/scallops,)(fs33), beef(f27), lamb (f88), fished-mixed 2(salmon/bass/carp, fs34) in the western blot, and to analyse the correlation CCD and plant-related allergens.Result Among the 94 patients, the majority of allergens-positive was t20,accounting for 60.6%, followed by f14 (59.6%), f13 (58.5%), ds1(57.4%) and CCD (56.4%);The prevalence of plant-related allergens (t20, w1, f14, f13, w6 and u80) in CCD-positive patients were significantly higher than those in CCD-negative patients (all P< 0.01); The prevalence of CCD in plant-related positive patients was significantly higher than that in plant-related negatived patients (all P< 0.01), and the CCD class-positive focused on class 3 to 4 in plant-related positive patients; 23% of the patients showed co-sensitization to all planted-related allergens ,and the prevalence of CCD increased with increasing co-sensitization cases; The correlation between t20 and w1 was the strongest(r = 0.77), followed by f13 and f14 (r = 0.56,), w6 and t20 (r = 0.55);there was different correlation among CCD and all plant-related allergens (r=0.39-0.84, all P<0.01), among which, the correlation of CCD with w1was the strongest(r=0.84); followed by correlation of CCD with t20(r=0.72).Conclusion Our study showed that the prevalence of plant-related allergens increased in CCD-positive patients and vice versa, Meanwhile, There was correlation, in varying degrees, among all plant-related allergens and CCD.

2018

abstract No: 

A1281 / P1022

Full conference title: 

The American Thoracic Society Conference 2018
    • ATS 2018