Activity of AREA and AREB under different carbon and nitrogen regimes

Ref ID: 18345

Author:

Maria Macios , Piotr Wëgleñski , Agnieszka Dzikowska

Author address:

Institute
1 1,2 1,2 1
of Genetics and Biotechnology, University of Warsaw, Poland Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland
adzik@ibb.waw.pl; marym@op.pl

Full conference title:

Asperfest 8

Abstract:

Nitrogen metabolite repression modulates the expression of target genes participating in utilization of alternative nitrogen sources, resulting in
transcription only when glutamine or ammonium levels are limiting. In Aspergillus nidulans this regulatory mechanism depends on a positively acting
regulator AREA. At variance with other pathways regulated by AREA, this factor functions as a repressor of arginine catabolism genes, acting concertedly
with the other GATA factor: AREB. The activities of AREA and AREB are differentially regulated by the carbon regime: AREA being necessary for the
ammonium repression of agaA and otaA under carbon repressing conditions, while AREB is primarily involved under carbon-limiting conditions. The
ability of both AREA and AREB to sense the status of carbon metabolism is most probably dependent on NMRA, and not on the transcription factor
CREA, which mediates general carbon catabolite repression is A. nidulans. Our current research is focused on investigation of the hypothesis of
AREA/AREB cooperation under different carbon and nitrogen regime.

Abstract Number: 23)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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