A combined genetic and multi medium approach reveals new secondary metabolites in Aspergillus nidulans.

Ref ID: 15878

Author:

Marie Louise Klejnstrup*, Morten
Thrane Nielsen, Jens Christian Frisvad, Uffe Mortensen, Thomas Ostenfeld Larsen. Department of Systems Biology,

Author address:

Department of Systems Biology, Technical University of Denmark,
Lyngby, Denmark,

Full conference title:

26th Fungal Genetics Conference

Date: 15 March 2014

Abstract:

Secondary metabolites are a diverse group of metabolites which serve as important natural sources of drugs for treating diseases. The availability of full
genome sequences of several filamentous fungi has revealed a large genetic potential for production of secondary metabolites that are not observed under
standard laboratory conditions. Genetic approaches have proven a fruitfull strategy towards the production and identification of these unknown
metabolites. Examples include deletion of the cclA1 and laeA2 genes in A. nidulans which affects the expression of secondary metabolites including
monodictyphenone and terrequinone A respectively. We have deleted the cclA gene in A. nidulans and grown the mutants on several complex media to
provoke the production of secondary metabolites. This resulted in the production of several metabolites not previously reported from A. nidulans. 1 Bok,
J.W. et al, Nat. Chem. Biol., 5, 462-464 (2009). 2 Bok J.W. et al, Chem. Biol., 13, 31-37 (2006).

Abstract Number: NULL

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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