Biosynthesis of prenylated alkaloids derived from tryptophan

Reference type: Book Section

Author:

Williams, R. M.;Stocking, E. M.;Sanz-Cervera, J. F.

Year published: 2000

Full title:

Biosynthesis of prenylated alkaloids derived from tryptophan

Secondary title:

Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids

Volume: 209

Pages: 97-173

Short title:

Biosynthesis of prenylated alkaloids derived from tryptophan

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Accession number: ISI:000088870100003

Keywords:

prenylated indole alkaloids; biosynthesis; paraherquamides; brevianamides; roquefortine; echinulin; verruculogen; cyclopiazonic acid; ergot alkaloids mammalian-cell cycle; stereocontrolled total synthesis; x-ray- analysis; aspergillus-fumigatus; penicillium-verruculosum; chemical modification; brevianamide-b; fumitremorgin-b; dimethylallyltryptophan synthase; tremorogenic metabolites

Abstract:

The biosynthesis of prenylated indole alkaloids and related natural substances derived from tryptophan is reviewed. The families of compounds covered in this review include the brevi- anamides, austamides, paraherquamides, marcfortine, roquefortine, aszonalenin, echinulin, verruculogen, the fumitremorgins, alpha-cyclopiazonic acid, and the ergot alkaloids. Although other families of naturally occurring prenylated indole alkaloids exist, such as the iridoids, this review is intended to examine the biosynthesis of the groups selected based on their structural and biogenetic similarities. In addition, the biosynthesis of the families selected for this chapter have not, to the best of our knowledge, been previously reviewed.

URL: ://000088870100003

Notes:

BQ58M

Author address:

Record number: 135

Category:

aspergillus