Here's our choice of review article highlights this month.
Diagnosis of severe respiratory infections in immunocompromised patients. Azoulay et al., 2020.
This review focuses on the diagnosis of severe respiratory infections in immunocompromised patients. Special attention is given to newly validated diagnostic tests designed to be used on non-invasive samples or bronchoalveolar lavage fluid and capable of increasing the likelihood of an early etiological diagnosis.
Antifungal Therapy: New and Evolving Therapies. Nivoix et al., 2020.
This article gives an overview of the mechanisms of action of currently used antifungals, as well as their spectrum of activity, clinically relevant pharmacological features, drug-drug interactions, and frequent side effects, all of which should inform the choice of agent when managing invasive fungal infections.
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species. Garcia-Rubio et al., 2020.
This paper reviews recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts and filamentous fungi (Aspergillus).