Little is currently known about the direct agonistic and antagonistic interactions between antifungals and other drug treatments. This is
Initially, a library of oncology drugs was screened for any that were recorded to interfere with the antifungal activity of either azoles or echinocandins, the 2 most widely used classes of systemic antifungals. 21 compounds from a library of 129 were identified, suggesting that this type of drug-drug interaction is more common than previously expected. A number of these compounds were then tested against Candida albicans, Candida
This study throws up many questions for future research and may be key to discovering why mortality rates for many fungal infections are so high.