Isavuconazole diffusion in infected human brain.


Rouzaud C, Jullien V, Herbrecht A, Palmier B, Lapusan S, Morgand M, Guéry R, Dureault A, Danion F, Puget S, Goldwirt L, Lanternier F, Lortholary O.
Antimicrob Agents Chemother. 2019 Aug 12. pii: AAC.02474-18


We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.