Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.

Author: 

Bozza S, Käsermann F, Kaveri SV, Romani L, Bayry J.
Eur J Immunol. 2018 Sep 29.

Abstract: 

Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation-dependent mechanism. The protection was associated with reduced recruitment of eosinophils, diminished goblet cell hyperplasia, suppressed Th2 and Th17 responses and reciprocally enhanced regulatory T cells and IL-10, and decreased IgE levels in the circulation.

KEYWORDS:

ABPA; Aspergillus fumigatus; IL-17F; IVIG; Tregs