Influence of Sustained Low-Efficiency Dialysis Treatment on Isavuconazole Plasma Levels in Critically Ill Patients.

Author: 

Lahmer T, Batres Baires G, Heilmaier M, Schmid RM, Sörgel F, Kinzig M, Huber W, Mayr U, Rasch S.
Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e01162-19.

Abstract: 

Isavuconazole plasma concentrations were measured before and after sustained low-efficiency dialysis (SLEDtreatment in 22 critically ill adult patients with probable invasive aspergillosis and underlying hematological malignancies. Isavuconazole levels were significantly lower after SLED treatment (5.73 versus 3.36 μg/ml; P < 0.001). However, even after SLED treatmentisavuconazole concentrations exceeded the in vivo MICs for several relevant Aspergillus species.