COVID-19 Associated Pulmonary Aspergillosis.

Author: 

Koehler P, Cornely OA, Böttiger BW, Dusse F, Eichenauer DA, Fuchs F, Hallek M, Jung N, Klein F, Persigehl T, Rybniker J, Kochanek M, Böll B, Shimabukuro-Vornhagen A.
Mycoses. 2020 Apr 27. doi: 10.1111/myc.13096. [Epub ahead of print]

Abstract: 

OBJECTIVES:

Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates Coronavirus disease 19 (COVID-19) associated invasive aspergillosis at a single center in Cologne, Germany.

METHODS:

A retrospective chart review of all patients with COVID-19 ARDS admitted to the medical or surgical intensive care unit at the University Hospital of Cologne, Germany.

RESULTS:

COVID-19 associated invasive pulmonary aspergillosis was found in five of 19 consecutive critically ill patients with moderate to severe ARDS.

CONCLUSION:

Clinicians caring for patients with ARDS due to COVID-19 should consider invasive pulmonary aspergillosis and subject respiratory samples to comprehensive analysis to detect co-infection.

KEYWORDS:

Aspergillus; ECMO; ICU; SARS-CoV-2; isavuconazole; voriconazole