Author:

Lather V, Chowdary PVR

Date: 4 April 2004

Abstract:

Several N’-(arylidine hydrazidomethyl)-indoles were prepared by condensing N’-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N’-indolyl acetamidyl) 4-oxo-thiazolidines were prepared by condensing N’-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococci aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with I standard drugs under the identical conditions.

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