Author:

Arber C, Bitmansour A, Shashidhar S, Wang S, Tseng B, Brown JM.

Date: 17 October 2005

Abstract:

Invasive fungal infections are a leading cause of morbidity and mortality after myelotoxic chemotherapy orradiation exposure. The resulting depletion of myeloid precursors under these conditions appears to be thefactor that limits approaches to accelerate immune reconstitution. In a murine model of myeloablation afterradiation exposure, we demonstrated that highly purified common myeloid and granulocyte-monocyte progenitors(CMPs/GMPs) accelerated myeloid recovery and, thus, enhanced innate immunity as measured bysurvival after a lethal challenge with Aspergillus fumigatus. Of greatest significance was the demonstrationthat the protection afforded by CMPs/GMPs was not major histocompatibility complex restricted.Furthermore,the effect of CMP/GMP cellular therapy was additive with that of liposomal amphotericin B treatment. Theseobservations greatly expand the potential donor pool and, thus, the clinical utility of CMP/GMP cellulartherapy in patients with myeloid depletion.

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