New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093

Author: Xu X, He F, Zhang X, Bao J, Qi S

Date: 17 January 2013


Nine mycotoxins including six aspergillic acid group toxins, aluminiumneoaspergillin (1), zirconiumneoaspergillin (2), aspergilliamide (3), ferrineoaspergillin (5), flavacol (6), neoaspergillic acid (7), and three ochratoxins, ochratoxin A n-butyl ester (4), ochratoxin A (8), ochratoxin A methyl ester (9), were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. SCSGAF0093. Four of them (1-4) were new mycotoxins, and their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The bio-toxicity of compounds 1-9 were determined by brine shrimp lethality bioassay with median lethal concentration (LC(50)) values of 2.59-205.67àŽÂ¼M. This was the first report about zirconium complex obtained from nature and ochratoxins isolated from marine environment.Copyright à‚© 2012 Elsevier Ltd. All rights reserved.

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