Morphology and development in Aspergillus nidulans: A complex puzzle
Author:
Steven D. Harris, Geoffrey Turner, Vera Meyer, Eduardo A. Espeso, Thomas Specht,Norio Takeshita, Kerstin Helmstedt
Date: 8 April 2009
Abstract:
Like other filamentous fungi, Aspergillus nidulans forms a multitude of cell types that facilitate colonizationand development. The molecular basis of cellular morphogenesis in A. nidulans is not well understood.Here, we summarize results obtained from detailed annotation of the A. nidulans genomesequence for genes with predicted roles in morphogenesis, with primary focus on polarized growth, calciumsignaling, and development. We draw three broad conclusions from our results. First, the componentsof the signal transduction pathways and morphogenetic machinery as defined in the modelyeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are largely conserved in A. nidulans. Second,A. nidulans possesses many additional genes implicated in morphogenesis that are not conserved inthese yeasts. Third, the number of A. nidulans genes involved in morphogenesis is likely to be rather large;based on our annotation, we estimate that as many as 2000 A. nidulans genes encode proteins that mayparticipate at some level in morphogenesis during vegetative growth and development.
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