Author:

Segal BH, Holland SM

Date: 16 June 2003

Abstract:

Chronic granulomatous disease Chronic granulomatous disease is an inherited disorder of the NADPH oxidase complex in which phagocytes are defective in generating the microbicidal reactive oxidant superoxide anion and its metabolites, hydrogen peroxide, hydroxyl anion, and hypohalous acid. As a result of the defect in this key host defense pathway, CGD patients suffer from recurrent life-threatening bacterial and fungal infections. CGD is also characterized by abnormally exuberant inflammatory responses leading to granuloma formation, such as granulomatous enteritis, genitourinary obstruction, poor wound healing, and dehiscence. CGD affects approximately 1 in 200,000 persons.

Link to DOI

Download the full article (Disclaimer)

This manuscript library of ~16,000 articles (1729-2024) related to Aspergillus and aspergillosis is intended for individual study only, and is provided as contribution to global understanding of the topic. Please refer to the publisher’s guidance about any other usage.

I understand (click to accept and view download link)

---