Interactions listed in the Paxlovid fact sheet, classified according to risks, pharmacological groups, and consequences.
Author:
Azanza JR, Mensa J, González Del Castillo J, Linares Rufo M, Molero JM, Madero Valle N, Barberán J.
Date: 13 July 2022
Abstract:
Paxlovid (nirmatrelvir plus ritonavir) is a new oral antiviral therapeutic for the treatment and post-exposure prophylaxis of COVID-19. Nirmatrelvir is an inhibitor of SARS-CoV-2 main protease, while ritonavir is used as a CYP3A inhibitor in low doses to slow the metabolism of nirmatrelvir, thus enhancing their therapeutic effect. The isoenzyme CYP3A4 is responsible for at least part of the oxidative metabolism of approximately 60% of available medications and ritonavir is therefore a significant source of drug interactions. We describe here the drugs that are contraindicated or should be used with or without precautions when Paxlovid (nirmaltrevir plus ritonavir) should be administered according to each fact sheet in force at the Spanish Agency for Medicines and Health Products.
Keywords: COVID-19; Drug interactions; Nirmatrelvir; Paxlovid; Ritonavir; SARS-CoV-2.
[Paxlovid (nirmatrelvir más ritonavir) es un nuevo tratamiento antivírico oral para la COVID-19. Nirmatrelvir es un inhibidor de la principal proteasa del SARS-CoV-2, mientras que ritonavir es usado como un inhibidor de la CYP3A a baja dosis para reducir el metabolismo de nirmatrelvir, potenciando así su efecto terapéutico. La isoenzima CYP3A4 es responsable de al menos una parte del metabolismo oxidativo de aproximada-mente el 60% de los medicamentos disponibles, por lo que el ritonavir es una fuente importante de interacciones farmacológicas. Describimos los fármacos cuyo uso está contraindicado o deben utilizarse con precauciones o sin ella cuando debe administrase Paxlovid (nirmaltrevir más ritonavir), de acuerdo con cada ficha técnica vigente en la Agencia Española de Medicamentos y Productos Sanitarios
Keywords: COVID-19; Drug interactions; Nirmatrelvir; Paxlovid; Ritonavir; SARS-CoV-2.]
Download the full article (Disclaimer)
This manuscript library of ~16,000 articles (1729-2024) related to Aspergillus and aspergillosis is intended for individual study only, and is provided as contribution to global understanding of the topic. Please refer to the publisher’s guidance about any other usage.