In vitro activity at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus

Author:

Verweij PE, Te Dorsthorst DT, Janssen WH, Meis JF, Mouton JW

Date: 16 October 2008

Abstract:

The antifungal agent flucytosine was found to be active in vitro against A. fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded with in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.

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