IL-4 Alpha chain receptor (IL-4Ra) polymorphisms in allergic bronchopulmonary aspergillosis
Author:
Alan P Knutsen, Barbara Kariuki, Judy D Consolino & Manoj R Warrier
Date: 5 March 2006
Abstract:
Background: Allergic bronchopulmonary aspergillosis occurs in 7-10% of cystic fibrosis (CF)and 1-2% of asthmatic patients. HLA-DR restriction and increased sensitivity to IL-4stimulation have been proposed as risk factors in these populations.Objective: We examined for the presence of IL-4 receptor alpha chain (IL-4Rα) singlenucleotide polymorphisms (SNPs) in ABPA and whether these accounted for increasedsensitivity to IL-4 stimulation.Methods: One extracellular (ile75val) and four cytoplasmic IL-4Rα SNPs were analyzed in 40CF and 22 asthmatic patients and in 56 non-ABPA CF and asthmatic patients. Sensitivity to IL-4 stimulation was measured by induction of CD23 expression on B cells.Results: IL-4Rα SNPs were observed in 95% of ABPA patients. The predominant IL-4Rα SNPwas the extracellular IL-4Rα SNP, ile75val, observed in 80% of ABPA patients.Conclusion: The presence of IL-4Rα SNPs, principally ile75val, appears to be a genetic risk forthe development of ABPA.
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