Identification of the mstE gene encoding a glucose inducible, low-affinity glucose transporter in Aspergillus nidulans.
Author:
Forment JV, Flipphi M, Ramon D, Ventura L, Maccabe AP.
Date: 7 February 2006
Abstract:
The mstE gene encoding a low-affinity glucose transporter active during the germination of Aspergillus nidulans conidia on glucose medium has been identified. mstE expression also occurs in hyphae, is induced in the presence of other repressing carbon sources besides glucose, and is dependent on the function of the transcriptional repressor CreA. The expression of MstE and its subcellular distribution have been studied using a MstE-sGFP fusion protein. Concordant with data on mstE expression, MstE-sGFP is synthesised in the presence of repressing carbon sources and fluorescence at the periphery of conidia and hyphae is consistent with MstE location in the plasma membrane. Deletion of mstE has no morphologically obvious phenotype but does result in the absence of low-affinity glucose uptake kinetics, the latter being substituted by a high-affinity system.
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