Glycosylinositolphosphoceramides in Aspergillus fumigatus
Author:
Simenel C, Coddeville B, Delepierre M, LatgÉ JP, Fontaine T
Date: 29 November 2007
Abstract:
Fungal glycosylinositolphosphoceramides (GIPCs) are involved in cell growth and fungal-host interactions. In this study, 6 GIPCs from the mycelium of the human pathogen Aspergillus fumigatus were purified and characterized using Q-TOF mass spectrometry and (1)H, (13)C and (31)P NMR. All structures have the same inositolphosphoceramide moiety with the presence of a C(18:0)-phytosphingosine conjugated to a 2-hydroxylated saturated fatty acid, (2-hydroxy-lignoceric acid). The carbohydrate moiety defines 2 types of GIPC. The first, a mannosylated zwitterionic glycosphingolipid contains a glucosamine residue linked in α1-2 to an inositol ring that has been described in only two other fungal pathogens. The second type of GIPC presents a α-Manp-(1->3)-α-Manp-(1->2)-IPC common core. A galactofuranose residue is found in 4 GIPC structures, mainly at the terminal position via a β1-2 linkage. Interestingly, this galactofuranose residue could be substituted by a choline-phosphate group, as observed only in the GIPC of Acremonium sp., a plant pathogen.
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