Epidemiology of Invasive Fungal Infections in Solid Organ Transplant Recipients: an Indian Perspective

Epidemiology of Invasive Fungal Infections in Solid Organ Transplant Recipients: an Indian Perspective

Author:

Megha Sharma, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti

Date: 20 October 2022

Abstract:

Purpose of Review: This review summarizes the available Indian data on epidemiology of invasive fungal infections (IFI)
in recipients of solid organ transplants (SOT). The epidemiology is further compared with studies from other parts of the
world for each SOT type.
Recent Findings: The available studies on Indian epidemiology of IFI in SOT are scarce, though the number of SOTs performed in India have increased tremendously in recent years. The limited data from India present a distinct spectrum of
infection in transplant recipients with high incidence of mucormycosis. During COVID-19 outbreak, IFI rate increased and
renal transplant recipients acquired mucormycosis earlier than previous studies.
Summary: Maximum data on IFI was available from renal transplant recipients, wherein mucormycosis was the predominant
IFI in Indian patients in contrast to invasive candidiasis in majority countries. The other IFIs had varied spectrum. With the
increasing number of SOTs being performed and the already persisting high burden of IFI in India, there is an urgent need
of larger prospective studies on epidemiology of IFI in transplant recipients.
Keywords: Invasive candidiasis · Mucormycosis · Epidemiology · Solid organ transplant

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