Author:

Baddley JW, Pappas PG, Smith AC, Moser SA.

Date: 22 December 2003

Abstract:

Invasive fungal infections due to Aspergillus species have become a major cause of morbidity and mortalityamong immunocompromised patients. Aspergillus terreus, a less common pathogen, appears to be an emergingcause of infection at our institution, the University of Alabama hospital in Birmingham. We therefore investigatedthe epidemiology of A. terreus over the past 6 years by using culture data; antifungal susceptibilitytesting with amphotericin B, voriconazole, and itraconazole; and molecular typing with random amplificationof polymorphic DNA-PCR (RAPD-PCR). During the study period, the percentage of A. terreus isolates relativeto those of other Aspergillus species significantly increased, and A. terreus isolates frequently were resistant toamphotericin B. Molecular typing with the RAPD technique was useful in discriminating between patientisolates, which showed much strain diversity. Further surveillance of A. terreus may better define epidemiologyand determine whether this organism is becoming more frequent in relation to other Aspergillus species.

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