Author:

Nakai T, Hatano K, Ikeda F, Shibuya K

Date: 29 November 2005

Abstract:

We performed a scanning and transmission electron microscopic study on theefficacy of micafungin (MCFG) to understand what kind of damage MCFG causesto Aspergillus and to confirm its previously reported in vitro killing activity againstAspergillus in a mouse model of pulmonary aspergillosis. Aspergillus hyphae inMCFG-treated mice displayed hyphal burst, evidenced as either flattened oratrophied appearance and leakage of cellular contents after collapse of the cell wall.Thus, MCFG can induce the destruction of Aspergillus hyphae at the focus ofinfection. The results of the present study indicate that MCFG improvespulmonary aspergillosis due to lethal damage to Aspergillus hyphae. This actioncan effectively reduce the invasive ability of Aspergillus even though MCFG doesnot sterilize the fungal burden.

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