Detection of gliotoxin in experimental and human aspergillosis.


Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA.

Date: 11 January 2005


Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

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