Author:

Oliver BG, Panepinto JC, Fortwendel JR, Smith DL, Askew DS, Rhodes JC

Date: 11 November 2005

Abstract:

This report describes the cloning and expression of both subunits of PKA in the opportunistic fungal pathogenAspergillus fumigatus. The predicted translation product of the regulatory subunit, pkaR, is defined as a type IIregulatory subunit. The gene encoding the A. fumigatus catalytic subunit, pkaC, contains the conserved kinase andactivation domains that are characteristic of PkaC proteins. Both subunit mRNAs are expressed throughout theasexual life cycle of A. fumigatus.Message levels of pkaR and pkaC are higher during co-cultivation with alveolarepithelial cells than during culture alone.

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