Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children.
Author:
Hsu AJ, Tamma PD, Fisher BT.
Date: 29 June 2022
Abstract:
Invasive aspergillosis (IA) is associated with significant morbidity and mortality. Voriconazole remains the drug of choice for the treatment of IA in children; however, the complex kinetics of voriconazole in children make dosing challenging and therapeutic drug monitoring (TDM) essential for treatment success. The overarching goal of this review is to discuss the role of voriconazole, posaconazole, isavuconazole, liposomal amphotericin B, echinocandins, and combination antifungal therapy for the treatment of IA in children. We also provide a detailed discussion of antifungal TDM in children.
Keywords: invasive aspergillosis; isavuconazole; posaconazole; therapeutic drug monitoring, immunocompromised children; voriconazole.
Download the full article (Disclaimer)
This manuscript library of ~16,000 articles (1729-2024) related to Aspergillus and aspergillosis is intended for individual study only, and is provided as contribution to global understanding of the topic. Please refer to the publisher’s guidance about any other usage.