Caspofungin susceptibility in aspergillus and non-aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.
Author:
Kahn JN, Hsu MJ, Racine F, Giacobbe R, Motyl M.
Date: 9 June 2006
Abstract:
Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.
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