Author:

Girmenia C, Ballaro D, Martino P

Date: 30 May 2007

Abstract:

Correspondence; no abstract. First paragraph: Galactomannan (GM) detection by the Platelia Aspergillus enzyme immunoassay is widely used for diagnosing invasive aspergillosis. A major problem with the detection of circulating GM is the occurrence of false-positive results due to the cross-reactivity of the test with antigens other than Aspergillus GM. In the clinical setting, cross-reactivity with antibiotics, in particular piperacillin-tazobactam, and other opportunistic fungi represent the two major causes of false-positive results. Gastrointestinal translocation of GM from food is also a presumed cause of false positivity for antigenemia. Recently, solutions containing gluconate, which is usually produced by fermentation of glucose in mold cultures, have been shown to be another cause of false-positive GM assay reactivity.

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