Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole.
Author:
Hall VG, Tang K, Kumar D, Rotstein C, Chow S, Chan SM, Husain S, Hosseini-Moghaddam SM.
Date: 16 March 2023
Abstract:
Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus those who did not. Subtherapeutic voriconazole levels and a triazole exposure history may contribute to breakthrough invasive fungal infection.
Keywords: breakthrough; invasive fungal infection; venetoclax; voriconazole.
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