Bioactive Alkaloids from Endophytic Aspergillus fumigatus
Ge HM, Yu ZG, Zhang J, Wu JH, Tan RX
Date: 6 April 2009
Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 knowncompounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compoundswere elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity againsthuman leukemia cells (K562) with an IC50 value of 3.1 μM, which was comparable to that of doxorubicin hydrochloride,a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neuriteoutgrowth of rat pheochromocytoma cells (PC12) at a 10.0 μM concentration.
Link to DOI:https://www.doi.org/10.1021/np800700e