Assessment of serum (1->3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Author:

Wiederhold NP, Najvar LK, Vallor AC, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF

Date: 14 January 2008

Abstract:

Serum (1->3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1->3)-β-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

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