Aspergillus galactomannan antigen detection with Platelia


V. Letscher-Bru, A. Cavalier, E. Pernot-Marino, H. Koenig, D. Eyer, J. Waller, E. Candolfi

Date: 1 January 1998


The detection of Aspergillus galactomannan antigen with the Platelia® Aspergillus test allows early diagnosis of invasive aspergillosis in immunocompromised patients. We observed a high rate of positive antigenemia in bone marrow transplant children without any sign of infection. In order to explore the origin of these false-positive results, we tested the presence of galactomannan in the foods supplied to these children. All foods containing cereals products were positives. These data suggest that the heat-resistant Aspergillus galactomannan which is not eliminated by sterilization processes may reach the circulation through damaged intestinal mucosa in these children and may cause false positive antigenemia.

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