Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones


Heeres J, Backx LJJ, Van Cutsem J

Date: 15 December 2008


A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.

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