Author:

Alagarsamy V

Date: 4 April 2004

Abstract:

A series of novel 2,3-disubstituted quinazolin-4(3H)-ones have been synthesized by condensing the aromatic primary amino group of quinazoline with different aldehydes and ketones. When these compounds were evaluated for antibacterial and antifungal activities, all the compounds inhibited the growth of bacteria and fungi significantly. The compounds VII and IX exhibited equipotent activity with the standard ciprofloxacin against Shigella flexneri, and Pseudomonas aeruginosa, and the compound VIII exhibited equivalent activity to ciprofloxacin against Bacillus subtillis and Citrobacter ferundii. The compounds V, VI and IX were found to be equipotent with the standard clotrimazole against Aspergillus niger and Microsporum gypseum; and the compound VI was equipotent with standard clotrimazole against Trichophyton mentagrophytes.

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