Alveolar macrophages are destroyed by their interaction with Aspergillus fumigatus condia and lung surfactant
Author:
C. Jarstrand, N. Gross, P. Camner, B. Zhivotovsky
Date: 21 May 2002
Abstract:
Aspergillus fumigatus conidia are ubiquitous, airborne, might colonize the lungs and cause chronic inflammation. We have found that when alveolar macrophages (AM) are challenged with A. fumigatus conidia, they increase their production and extracellular release of reactive oxygen species (ROS). This increases lipid peroxidation (LPO) of lung surfactant by AM.
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