Advances and challenges in management of invasive mycoses
Author:
Thomas F Patterson
Date: 13 November 2005
Abstract:
Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnosticmethods offer the potential for improved outcomes in patients with these infections, which are often lethal. Manyfungal pathogens occur almost exclusively in opportunistic settings—in the immunocompromised host—and theseinfections are the focus of this review. Several areas of ongoing challenge remain, including the emergence ofresistant organisms and the absence of reliable markers for early identification of patients at risk of developinginvasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnosticmethods, and recent therapeutic options and current management strategies for these opportunistic pathogens.
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