Aspergillus Newsletter

eNewsletter: June 6, 2008

Living with it, Working with it, Treating it

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ECCMID abstracts, posters and slide presentations

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The Aspergillus website has 35000 registered members (5% Vets, 27% Medical, 22% Science) and provides up to 9 million page requests per year.

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Merger with CADRE

DNA/protein interractionCADRE has merged with the Aspergillus website, effectively taking over the old genomics section of the website which now becomes the 'Aspergillus Genomes' section.

CADRE contains the complete genome sequences of seven separate strains/species of Aspergillus - a staggering 256,692,138 base pairs or over a quarter of a billion base pairs, with more species to come soon!

This massive resource is fully annotated and searchable/analysable using ensemble software. This makes the Aspergillus Website the most comprehensive resource for Aspergillus genomic sequence data available.

This month

Latest statistics on usage of the Aspergillus Website show further marked increases of the website in our 10th Anniversary Year. 12 months ago we were supplying 3 million pages per year whereas the figures for march 2008 show a rate equivalent to nearly 9 million pages requests per year.

We are re-launching the 'Tech-tips' group for researchers in Aspergillus. The group is several years old but has always been quite a low activity group. The point about such a group is that once a large enough group of members is signed up there will be a pool of experience that can mutually support each other. The group currently has 70 members so that is a good start - please join up

We have also found some excellent videos of a dive team surveying the devastation of sea fan corals off the Florida Coast by Aspergillus sydowii - the same team that donated the still images of infected sea fans some years ago, led by Dr Kiho Kim

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Latest News and Articles

There have been 28 additions to the articles section. We have picked out a few of the highlights here:

Development of an immuno-chromatographic lateral flow device for the rapid serodiagnosis of invasive aspergillosis

This device uses an Aspergillus specific monoclonal antibody to an epitope secreted by growing Aspergillus, and which is therefore found in the blood of infected people. The lateral flow device is similar to those used for early pregnancy testing and is very rapid, giving a result in 15 mins.

Testing of blood samples from a small number (12) of known or suspected invasive aspergillosis cases gave comparable or better clinical sensitivity to established galactomannan tests e.g. Platelia.

Reappraisal of the Serum (1r3)-b-D-Glucan Assay for the Diagnosis of Invasive Fungal Infections— A Study Based on Autopsy Cases from 6 Years
A reappraisal of 456 autopsies shows 12% dying due to invasive fungal infection, 70% of which being Aspergillus infections (IA). Sensitivity and specificity of the ß-glucan assay was 95% and 86% respectively with cutoff of 30pg/ml. The conclusion was that ß-glucan remains an effective tool in the diagnosis of IA.

Fungal brain infections

A review of CNS aspergillosis. Cases are getting more common as the immunocompromised population grows, and early diagnosis is important.

"The specific infectious risk posed by novel immune-modifying therapies can, in most cases, be predicted on the basis of the immune target and medication timing. In addition, major advances in noninvasive diagnostic tests (e.g. serum beta glucan and galactomannan assays), and the recent introduction of more effective antifungal therapies, have led to a dramatic improvement in clinical outcomes."

Air conditioning systems in cars: management with respect to minimising mould growth

A recent news report recommended that owners of vehicles with air conditioning units run the units at least once per week to prevent a build up of mould in the system. This was inspired by the rising price in fuel around the world making it more likely that owners would leave air-con units switched off for long periods to save fuel.

A closer look at the situation in our blog suggests that people vulnerable to mould spores should leave their air-con switched off permanently.

Diagnosis

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.

New definitions for invasive disease released by EORTC/MSG.

Endoscopic xamination of the outer ear: Typical image of an external otitis involving Aspergillus niger has been added to the clinical part of the Educational and Teaching Tools section

Histology: New movies describing how to analyse slides of lung tissue with invasive Aspergillosis have been added to the Educational and Teaching Tools section.

 

Reviews

Aspergillus-associated Hypersensitivity Respiratory Disorders by Ashok Shah (Vallabhbhai Patel Chest Institute, University of Delhi) looks at disorders such as ABPA and AAS and their changing inter-relationships. He also strongly features the rising important of fungi in asthma.

"The clinical spectrum of Aspergillus-associated hypersensitivity respiratory disorders includes Aspergillus induced asthma, allergic bronchopulmonary aspergillosis (ABPA), allergic Aspergillus sinusitis (AAS) and hypersensitivity pneumonitis. Inhalant allergens, in patients with allergic asthma, play a key role in bringing about the inflammation present in the airways, and fungi are increasingly being recognised as important inhalant allergens. Aspergillus is linked to asthma in more ways than one"

Treatment

Following the extensive update of our article on Invasive Pulmonary Aspergillosis, Adam Jeans has updated our article on thyroiditis in the Treatment section.

Conference Abstracts

Abstracts and posters are being added for 48th & 49th ASH

Air Quality

A short series of video's have been added. Produced by Rutgers University with the aid of the EPA in the US these educational video's are intended to provide advice on detecting poor indoor air quality, prevention and cure for the layperson.

 

Patients

The website has been updated and streamlined, with a single Question and Answer page and a single Support group which we hope will improve our service to patients.

Genomes

See top of page

CGD

CGD logoA new support group for chronic granulomatous disorder has been initiated as a Yahoo group following the very successful model set out by the Aspergillus support group. To join the group, backed up by Marie Kirwan CGD Specialist Nurse, click on the link above.

Technical Tips

Our discussion group (email and/or website) designed to promote discussion on technical issues for laboratory workers.

Searching the website

We now have a dedicated Google Search Appliance for this website. This means you can search the Aspergillus website using Google and it will include nearly all documents on the website (pdf, doc, ppt, html, php etc). and will include parts of the secure sections and eventually index images - a big improvement on earlier search facilites. Try it out here.

HonCode

HonCode accreditationHealth on the Net Foundation (HonCode) are the formost accrediation service for health-oriented websites. The Aspergillus website has been accredited since 1999 and this has once again been reaffirmed after the latest review in August 2007

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The Aspergillus Team.

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