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Published interaction studies of itraconazole and corticosteroids |
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| Itraconazole
is an inhibitor of cytochrome P450 3A4. It increases exposure to
methylprednisolone (Varis et al, 1999; Lebrun-Vignes et al, 2001),
dexamethasone (Varis et al, 2000), budesonide (Raaska et al, 2002)
and probably fluticasone (Parmar et al, 2002), but not prednisolone
(Variset al 2000; Lebrun-Vignes et al, 2001) or endogenous cortisol
(Phillips et al, 1987; Queiroz-Telles F et al, 1997). No published
study has addressed any interaction of itraconazole and beclomethasone.
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David W. Denning FRCP FRCPath FIDSA FMedSci August 2003 |