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Whilst the Aspergillus Website & the Fungal Research Trust have taken every precaution in compiling this site, neither it nor any contributors or charity Trustees can be held responsible for using the information held herein. Medical information changes constantly and the information presented here should not be considered complete or exhaustive and should not be relied upon as the sole or primary source on which to base diagnosis or treatment for any individual. This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and links to other sites, the Aspergillus Website provides general information for educational purposes only. The information provided in this site, or through links to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call, consultation or the advice of your physician or other healthcare provider. Neither The Aspergillus Website nor the FRT is liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. I have read this, proceed to the article |
Aortic graft infection by Aspergillus |
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Aortic bypass graft material may become infected with Aspergillus (Echenne et al, 1980; Glotzbach. 1982; Anderson & Kron, 1984; Hargrove & Edmunds, 1984; Brandt et al, 1985; Nussaume et al, 1990; Aguado et al, 1992; Banzo et al, 1992; Motte et al, 1993). Most cases are probably attributable to airborne contamination at the time of surgery as has been reported in numerous instances. Aspergillus fumigatus, Aspergillus terreus (amphotericin B resistant) and Aspergillus flavus have all been implicated. In most cases, presentation occurs weeks or months after surgery typically one to six months and less often two to three years later. Either the aortic or thoracic aorta may be involved. Direct extension to vertebral bodies was observed in some patients. All survivors have received antifungal therapy, had the original graft resected and had an extraanatomic bypass created. Localised extension to, for example, the vertebral column requires treatment as for osteomyelitis. David W. Denning FRCP FRCPath FIDSA FMedSci |