| Secondary metabolites trivial name - penicillic acid | ||||||||||||||||||||
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| Species | A. melleus, A. ochraceopetaliformis, A. ochraceus, A. ostianus | |||||||||||||||||||
| Systematic name | 2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo- | |||||||||||||||||||
| Molecular formulae | C8H10O4 | |||||||||||||||||||
| Molecular weight | 170.163 | |||||||||||||||||||
| Chemical abstracts number | 90-65-3 | |||||||||||||||||||
| PubChem URL | Go to PubChem link | |||||||||||||||||||
| Selected references | Holker, John S. E.; Simpson, Thomas J. (Dep. Org. Chem., Univ. Liverpool, Liverpool L69 3BX, Engl.). J. Chem. Soc., Perkin Trans. 1, (5), 1397-400 (English) 1981.
Penicillic acid.IARC Monogr Eval Carcinog Risk Chem Man. 1976;10:211-6. Review. Awad G, Mathieu F, Coppel Y, Lebrihi A. Characterization and regulation of new secondary metabolites from Aspergillus ochraceus M18 obtained by UV mutagenesis. Can J Microbiol. 2005 Jan;51(1):59-67. Natori S, Sakaki S, Kurata H, Udagawa S, Ichinoe M. Chemical and cytotoxicity survey on the production of ochratoxins and penicillic acid by Aspergillus ochraceus Wilhelm. Chem Pharm Bull (Tokyo). 1970 Nov;18(11):2259-68. Namikoshi M, Negishi R, Nagai H, Dmitrenok A, Kobayashi H. J Antibiot (Tokyo). 2003 Sep;56(9):755-61. Three new chlorine containing antibiotics from a marine-derived fungus Aspergillus ostianus collected in Pohnpei. | |||||||||||||||||||
| Toxicity | mouse LD50 intraperitoneal 90mg/kg (90mg/kg) Toxicology and Applied Pharmacology. Vol. 52, Pg. 1, 1980.
Link to PubMed mouse LD50 intravenous 250mg/kg (250mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946. mouse LD50 oral 600mg/kg (600mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946. mouse LD50 subcutaneous 100mg/kg (100mg/kg) "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1122, 1989. mouse LDLo unreported 280mg/kg (280mg/kg) British Journal of Cancer. Vol. 15, Pg. 85, 1961. Link to PubMed rat LD50 intraperitoneal 90mg/kg (90mg/kg) LIVER: EFFECTS: OTHER CHANGES Journal of Toxicology and Environmental Health. Vol. 7, Pg. 169, 1981. Link to PubMed | |||||||||||||||||||
| Structure diagram | ![]() | |||||||||||||||||||
| 3D Structure | ![]() | |||||||||||||||||||
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