Secondary metabolites trivial name - penicillic acid
Species A. melleus, A. ochraceopetaliformis, A. ochraceus, A. ostianus
Systematic name 2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-
Molecular formulae C8H10O4
Molecular weight 170.163
Chemical abstracts number 90-65-3
PubChem URL Go to PubChem link
Selected references Holker, John S. E.; Simpson, Thomas J. (Dep. Org. Chem., Univ. Liverpool, Liverpool L69 3BX, Engl.). J. Chem. Soc., Perkin Trans. 1, (5), 1397-400 (English) 1981.
Penicillic acid.IARC Monogr Eval Carcinog Risk Chem Man. 1976;10:211-6. Review.
Awad G, Mathieu F, Coppel Y, Lebrihi A. Characterization and regulation of new secondary metabolites from Aspergillus ochraceus M18 obtained by UV mutagenesis. Can J Microbiol. 2005 Jan;51(1):59-67.
Natori S, Sakaki S, Kurata H, Udagawa S, Ichinoe M. Chemical and cytotoxicity survey on the production of ochratoxins and penicillic acid by Aspergillus ochraceus Wilhelm. Chem Pharm Bull (Tokyo). 1970 Nov;18(11):2259-68.
Namikoshi M, Negishi R, Nagai H, Dmitrenok A, Kobayashi H. J Antibiot (Tokyo). 2003 Sep;56(9):755-61. Three new chlorine containing antibiotics from a marine-derived fungus Aspergillus ostianus collected in Pohnpei.
Toxicity mouse LD50 intraperitoneal 90mg/kg (90mg/kg) Toxicology and Applied Pharmacology. Vol. 52, Pg. 1, 1980. Link to PubMed
mouse LD50 intravenous 250mg/kg (250mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946.
mouse LD50 oral 600mg/kg (600mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946.
mouse LD50 subcutaneous 100mg/kg (100mg/kg) "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1122, 1989.
mouse LDLo unreported 280mg/kg (280mg/kg) British Journal of Cancer. Vol. 15, Pg. 85, 1961. Link to PubMed
rat LD50 intraperitoneal 90mg/kg (90mg/kg) LIVER: EFFECTS: OTHER CHANGES Journal of Toxicology and Environmental Health. Vol. 7, Pg. 169, 1981. Link to PubMed
Structure diagram
3D Structure
Automatic database searches PubMed - 15 million citations from MEDLINE and other life science journals.
Search Pubmed for penicillic acid
ChemIDplus - Dictionary of over 370,000 chemicals (names, synonyms, and structures).
Search by chemical abstracts number: 90-65-3
ChemIDplus - Dictionary of over 370,000 chemicals (names, synonyms, and structures). Search by trivial name: penicillic acid
Search Toxicology Literature Online (TOXLINE) Search TOXLINE for penicillic acid
Search Developmental and Reproductive Toxicology Database (DART) Search DART for penicillic acid
Hazardous Substances Data Bank (HSDB) Search HSDB for penicillic acid
Genetic Toxicology Data Bank (GENE-TOX) Search GENE-TOX for penicillic acid
Chemical Carcinogenesis Research Information System (CCRIS) Search CCRIS for penicillic acid
   
back

Disclaimer | Privacy/Confidentiality | Cookies | Terms and Conditions | Advertising
This page was created by Dr Graham Atherton PhD on March 13 2006
This page was last modified: February 06 2013 11:52:22.
Maintained by Aspergillus Website Team