Secondary metabolites trivial name - ochratoxin A
Species A. affinis, A. albertensis, A. alliaceus, A. auricomus, A. carbonarius, A. citricus, A. fonsecaeus, A. lanosus, A. melleus, A. niger, A. ochraceopetaliformis, A. ochraceus, A. ostianus, A. petrakii, A. sclerotiorum, A. sulphureus
Systematic name 2-(5-chloro-8-hydroxy-3-methyl-1-oxo-isochroman-7-yl)carbonylamino-3-phenyl-propanoic acid
Molecular formulae C20H18ClNO6
Molecular weight 403.813
Chemical abstracts number 303-47-9
PubChem URL Go to PubChem link
Selected references van der Merwe KJ, Steyn PS, Fourie L, Scott DB, Theron JJ. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 1965 Mar 13;205(976):1112-3.
Toxicity Potent nephrotoxin implicated in porcine nephropathy. Acute oral LD50 in the male rat 30.3 mg/kg body-weight and in the female rat 21.4 mg/kg body-weight. Recent assessments of toxicity suggest that this compound may be carcinogenic and genotoxic.

chicken LD50 oral 3300ug/kg (3.3mg/kg) EFFECTS: CARDIAC: PERICARDITIS LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES Applied Microbiology. Vol. 21, Pg. 492, 1971. Link to PubMed
chicken LDLo subcutaneous 11mg/kg (11mg/kg) EFFECTS: LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" Applied Microbiology. Vol. 21, Pg. 492, 1971. Link to PubMed
domestic animals - goat/sheep LD50 intravenous 1mg/kg (1mg/kg) EFFECTS: LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES CRC Critical Reviews in Toxicology. Vol. 2, Pg. 499, 1974. Link to PubMed
duck LD50 oral 500ug/kg (0.5mg/kg) EFFECTS: LIVER: FATTY LIVER DEGERATION Nature. Vol. 205, Pg. 1112, 1965. Link to PubMed
mouse LD50 intraperitoneal 22mg/kg (22mg/kg) Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.
mouse LD50 intravenous 25710ug/kg (25.71mg/kg) EFFECTS: BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
mouse LD50 oral 46mg/kg (46mg/kg) Toxicology Letters. Vol. 25, Pg. 1, 1985. Link to PubMed
quail LD50 oral 16500ug/kg (16.5mg/kg) EFFECTS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA Poultry Science. Vol. 55, Pg. 786, 1976. Link to PubMed
rat LD50 intraperitoneal 12600ug/kg (12.6mg/kg) EFFECTS: BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH SKIN AND APPENDAGES (SKIN): HAIR: OTHER Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
rat LD50 intravenous 12750ug/kg (12.75mg/kg) EFFECTS: BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
rat LD50 oral 20mg/kg (20mg/kg) EFFECTS: LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA Food and Cosmetics Toxicology. Vol. 6, Pg. 479, 1968. Link to PubMed
rat LD50 unreported 22mg/kg (22mg/kg) Indian Journal of Experimental Biology. Vol. 29, Pg. 813, 1991. Link to PubMed
turkey LD50 oral 5900ug/kg (5.9mg/kg) EFFECTS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA Poultry Science. Vol. 55, Pg. 786, 1976. Link to PubMed
Structure diagram
3D Structure
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