Aspergillus galactomannan antigen detection with Platelia®

Taken from:

J Mycol Méd
1998 ; 8 : 112-113

Original article in French by:

V. Letscher-Bru1, A. Cavalier2, E. Pernot-Marino1, H. Koenig1, D. Eyer2, J. Waller1, E. Candolfi1
1 Institut de Parasitologie et de Pathologie tropicale (Pr. Kien), Faculté de Médecine de Strasbourg
2 Service d'Onco-Hématologie pédiatrique (Pr. Lutz), Hôpitaux Universitaires de Strasbourg.

Summary

The detection of Aspergillus galactomannan antigen with the Platelia® Aspergillus test allows early diagnosis of invasive aspergillosis in immunocompromised patients. We observed a high rate of positive antigenemia in bone marrow transplant children without any sign of infection. In order to explore the origin of these false-positive results, we tested the presence of galactomannan in the foods supplied to these children. All foods containing cereals products were positives. These data suggest that the heat-resistant Aspergillus galactomannan which is not eliminated by sterilization processes may reach the circulation through damaged intestinal mucosa in these children and may cause false positive antigenemia.

Positive antigens Negative antigens
Puffed chocolate cereal Low fat yoghurt
Puffed corn petals Sweetened yoghurt
Honeyed corn flakes Goat's cheese
Bread (unsalted) Potato rissoles
Macaroni (curved) Veal
Rice (salted) Carrots (unsalted) with cream
Dry cakes Carrots (salted) with cream
Shepherd's pie Sweetcorn
Turkey slices Vinaigrette
Grilled sausage Mint syrup
Veal casserole in white sauce Lemon syrup
Gratin dauphinoise Grenadine syrup
Roast chicken (unsalted)
Bolognese sauce (salted)  
Puffed rice  
Chips (french fries)  
Crème caramel  
Crisps  

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