Chronic granulomatous disorder (CGD) is the result of a genetic mutation and causes excessive inflammation. Invasive mould infection is the most significant cause of mortality in CGD, and Aspergillus is the most common cause of pneumonia for people with this condition, so the need to destroy the Aspergillus but minimise inflammation calls for treatment with a combination of antifungal agents and steroids. |
However, there are often few signs that people are infected.
Dr Segal makes the case for prevention of aspergillosis in CGD, including prophylactic use of antifungals and avoidance of exposure to mould.
With thanks to Fran Stokes |