New antifungals drugs, new approaches and vaccines

Title Antifungal name Trial phase Date
Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase. AR-12 23 Feb 2016
AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication. AR-12 1 Oct 2016
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis. AR-12 1 Dec 2016
Trans-ungual Delivery of AR-12, a Novel Antifungal Drug. AR-12 13 Mar 2017
ram1 gene, encoding a subunit of farnesyltransferase, contributes to growth, antifungal susceptibility to amphotericin B of Aspergillus fumigatus. Manumycin A 4 Feb 2017
In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida. Tipifarnib 5 Dec 2013
In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida. Manumycin A 5 Dec 2013
Evaluation of the antifungal activity of SCY-078 in combination with other antifungals against Aspergillus strains SCY-078 (MK-3118) 27 Apr 2017
Pharmacodynamics of F901318 against Aspergillus fumigatus in a rabbit model of invasive pulmonary aspergillosis (IPA) F901318 27 Apr 2017
A prospective, phase 2, multicentre, open-label, randomized, comparative study to estimate the safety, tolerability, pharmacokinetics, and efficacy of oral SCY-078 vsstandard-of-care following initial intravenous echinocandin therapy in the treatment of.. SCY-078 (MK-3118) Phase 2 27 Apr 2017

Pages