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Piles of Rotting Woodchip A pile of woodchip stored for use in a garden usually as a weed suppressing mulch. The heat Image 1, Image 2, Image 3
Image 1, Image 2, Image 3 Piles of Rotting Woodchip A pile of woodchip stored for use in a garden usually as a weed suppressing mulch. The heat
Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A October 2016, January 2017
October 2016, January 2017 Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A

A bronchoscopy found large amounts of mucous that was suctioned and removed. Aspergillus was found in the mucous on microscopy and A. fumigatus grown in culture. 

She felt better immediately and a follow up scan shows re-expansion of the right middle and lower lobes. 

A diagnosis of Aspergillus bronchitis was made based on the bronchoscopy findings, microscopy and culture results and supported by an positive Aspergillus IgG of 97mg/L (ImmunoCap). 

Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis) Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles.
Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles. Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis)
Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later.
Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later. Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole
Cresemba Cresemba (Isavuconazole)
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus

Scanning Electron Micrograph of germinating Aspergillus fumigatus spores (provided by KM Lord and ND Read)

Aspergillus niger Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya A niger conidial head TEM in vitro, A niger mature conidium TEM in vitro
A niger conidial head TEM in vitro, A niger mature conidium TEM in vitro Aspergillus niger Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya
Aspergillus terreus Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova A terreus aleurospore TEM in vitro, A terreus mature conidium SEM in vitro, A terreus mature conidial head SEM in vitro
A terreus aleurospore TEM in vitro, A terreus mature conidium SEM in vitro, A terreus mature conidial head SEM in vitro Aspergillus terreus Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova
Electron Microscopy: Aspergillus fumigatus Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova Conidial head (SEM), Part of conidial head (SEM), Mature conidia (SEM), Hyphae (SEM), Murine lung tissue (TEM)
Conidial head (SEM), Part of conidial head (SEM), Mature conidia (SEM), Hyphae (SEM), Murine lung tissue (TEM) Electron Microscopy: Aspergillus fumigatus Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova
Aspergillus clavatus Isolate from environmental sample A. clavatus, A. clavatus, A. clavatus
A. clavatus, A. clavatus, A. clavatus Aspergillus clavatus Isolate from environmental sample
Sputum plug Fungal plug Fungal plug
Fungal plug Sputum plug Fungal plug

Fungal plug, Image sent in by ptPC-W. Patient female aged 70 years, Image taken on 3/12/2014

ABPA complicated by severe varicose bronchiectasis Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated December 2012, May 2012, December 2012, February 2010
December 2012, May 2012, December 2012, February 2010 ABPA complicated by severe varicose bronchiectasis Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated

The CT scan (3 cuts from the same scan in 2012) shows background  paraseptal  and  centrilobular  emphysema  and  the  distribution  of  the  varicoid  bronchiectasis (i.e. upper lobe predominant and central)  is  consistent  with  ABPA.  There  are no  areas  of  consolidation  or  evidence  of  interstitial  lung  disease.  Several fluid  levels  are seen within  the  airways  together with bronchial  wall  thickening   throughout  the  right  hemithorax. There  is  almost  no evidence  of  exudative  small  airways  disease  (i.e.  no  small  airway  impaction).

The chest Xrays show mild  cardiomegaly.  There are  background  chronic  interstitial  changes  of  a  coarsened  reticulonodular  pattern,  with  an  area  of more  prominent  pulmonary  fibrotic  change  in  the  right  mid  zone.    Minor apical thickening noted.   

Ira F. Salkin 1941-2016
Ira F. Salkin 1941-2016

Obituary written on ISHAM website:

December 21, 1941- March 2, 2016
It is with deep sadness that we announce that Ira F. Salkin, PhD died on March 2, 2016 having lost his long battle with COPD and congestive heart failure.  His passing is a great loss to the community of medical mycology.  Born in Chicago, Ira attended Northwestern University for both his Bachelors and Master degrees (1959-1964) prior to moving west to earn his PhD in 1969 from the University of California, Berkeley.  Ira began a long career in mycology with his doctoral work, where he used his NSF pre-doctoral award to study the biology of aquatic fungi.  Upon completion of his PhD he moved east to Albany New York where he spent the next 32 years with the New York State Department of Health in the Wadsworth Laboratories, later to become a Director of numerous State laboratories and programs.  These included the Medical Mycology Laboratories, Clinical Laboratory Approval Program, Biological Safety, Medical Waste and Quality Control.  During his career he published more than 120 articles in peer-reviewed journal and chapters in textbooks.

Ira was deeply involved in several scientific societies and was recognized by his peers for his energetic efforts in these societies. He was a long-standing member the American Society for Microbiology, was the Chair of Division F in 1990-91 and was elected as a Fellow of the American Academy of Microbiology.  He received the Lippmann Award for Scientific Achievement of the Medical Mycology Society of New York. In 1991, Ira was awarded the Billy H. Cooper award from the Medical Mycology Society of the Americas in recognition of his efforts in clinical mycology, as well as the Meridian Award.  In 2015, Ira was granted the Distinguished Service award by ISHAM, which speaks for itself.

Ira’s great passion was scientific publication ranging from the ethics of publication to journal editing, which amounted to possibly some of his greatest contributions Over  the last 25 years Ira served as an Editor of the Journal of Clinical Microbiology from 1990-2000, the Editor-in-Chief of the Journal of Applied Biosafety from 2001-2004, and from 2004 through 2015 he was the Editor-in-Chief of Medical Mycology. This also made him an ex officio member of the Council of ISHAM.  As part of his efforts for Medical Mycology he organized very popular sessions at three separate ISHAM congresses directed toward young scientists on how to write and publish a scientific paper.  His speaking style and wit, intermingled with his pearls of publishing and writing wisdom, were always well received. He was a  very difficult act to follow especially if you were the next speaker. His efforts as the Editor in Chief of ISHAM’s own journal, Medical Mycology, were unparalleled as he raised the visibility and impact of the journal but also improved the quality of many articles as copy editor and even smoothed the grammar of the accepted manuscripts.  This may not always have been received well but most authors were very pleased once they saw their work in press. As relayed to us by his loving wife Kay, “Ira was always happiest when sitting at his computer working on a manuscript”.

For those of us privileged to know Ira well, he was a man with a very quick, dry wit, had an eager willingness to “argue” a point aggressively without hostility and was someone who had  vast life experience, which he was willing to share especially over a night cap of a good malt uisge beatha or "water of life" of Scottish provenance.  His liberal views in politics and other areas, possibly a holdover from his days in Berkeley in the ‘60’s, guided these discussions.  Ira enjoyed many informal symposia i.e., a fine meal  and libation during which he and his companions solved many of the problems of the world.  Ira was a good colleague and a great friend to many and selflessly put others ahead of himself.  He was indeed a scholar and a gentleman. Those of us who counted Ira a friend will miss him greatly. The Medical Mycology community has also lost one of its shining beacons.
Ira is survived by his devoted wife, Kay (Brown) Salkin; stepdaughters, Lori Hewig and Beth (Gerard) Weir; stepson, William (Tracy) Schwarz; son, Daniel; and grandchildren, Lindsay and Elise Weir, and Benjamin and Cameran Schwarz. Ira was pre-deceased by parents, Irving and Mollie Salkin, and brother, Marshall Salkin. 

We invite anyone wishing to relate a story concerning Ira to send it to the ISHAM website for inclusion in this tribute to an important member of the Medical Mycology community.

Karl V. Clemons, Chester R. Cooper, J. Peter Donnelly
April, 2016

Haemofungin
E1210 structure

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