Word search

Displaying 1 - 15 of 2507
Title Legend Grouping
William Ernest Dismukes 1939-2017
William Ernest Dismukes 1939-2017

William Ernest Dismukes, MD, Professor Emeritus and former head of the Division of Infectious Diseases at the University of Alabama at Birmingham (UAB) School of Medicine, passed away peacefully on 19 June 2017, at the age of 78 years. Bill made important contributions to the field of clinical mycology and infective endocarditis through his scientific and clinical observations, educational efforts, involvement in the development of clinical trials, and leadership in the development of treatment guidelines. The treatment guidelines for fungal infections were the first of their kind and were among the most oft-quoted and influential standards available at the time.

Read the full obituary here

Haemoptysis pt AS , ,
, , Haemoptysis pt AS

ptAS is seen at the National Aspergillosis Centre in Manchester, UK and has ABPA and bronchiectasis

Skin lesions in patient with acute myeloid leukemia Images and abstract taken from Mert D et.al., Hematol Rep. 2017 Jun 1;9(2):6997. doi: 10.4081/hr.2017.6997. Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.Invasive read more... Zosteriform scatris on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Bullous lesions on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Zosteriform scatris with erythematous halo on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Histological findings of invasive cutaneous aspergillosis. Skin biopsy showing fungal hyphae accumulated in the dermiş., Non-branching fungal hyphae and intensive neutrophil infiltration in the dermis. Fungal infiltration also seemed to invade the vessels.
Zosteriform scatris on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Bullous lesions on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Zosteriform scatris with erythematous halo on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Histological findings of invasive cutaneous aspergillosis. Skin biopsy showing fungal hyphae accumulated in the dermiş., Non-branching fungal hyphae and intensive neutrophil infiltration in the dermis. Fungal infiltration also seemed to invade the vessels. Skin lesions in patient with acute myeloid leukemia Images and abstract taken from Mert D et.al., Hematol Rep. 2017 Jun 1;9(2):6997. doi: 10.4081/hr.2017.6997. Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.Invasive read more...
Aspergillus flavus A. flavus isolated from aural debris
A. flavus isolated from aural debris Aspergillus flavus Image provided by Prof Malcolm Richardson, Mycology Reference Centre Manchester
AR-12 For further details go to the new antifungal drugs section AR-12 (Antitumor/Antifungal Celecoxib Derivative)
AR-12 (Antitumor/Antifungal Celecoxib Derivative) AR-12 For further details go to the new antifungal drugs section
Tipifarnib Farnesyltransferase inhibitor - see new Antifungal drugs section for more details Tipifarnib (farnesyltransferase inhibitor)
Tipifarnib (farnesyltransferase inhibitor) Tipifarnib Farnesyltransferase inhibitor - see new Antifungal drugs section for more details
Manumycin A Farnesyltransferase inhibitor - see New Antifungal drugs section for more details Manumycin A (farnesyltransferase inhibitor)
Manumycin A (farnesyltransferase inhibitor) Manumycin A Farnesyltransferase inhibitor - see New Antifungal drugs section for more details
Case 66: Aspergillus invasive skin graft infection in a child suffering from severe burns. Figure 1. Case history number 66
Piles of Rotting Woodchip A pile of woodchip stored for use in a garden usually as a weed suppressing mulch. The heat building up in the pile is illustrated by the plumes of steam eminating from the top of the pile.Aspergillus fumigatus is particularly well adapted to grow read more... Image 1, Image 2, Image 3, Image 4. Note visible mould growth.
Image 1, Image 2, Image 3, Image 4. Note visible mould growth. Piles of Rotting Woodchip A pile of woodchip stored for use in a garden usually as a weed suppressing mulch. The heat building up in the pile is illustrated by the plumes of steam eminating from the top of the pile.Aspergillus fumigatus is particularly well adapted to grow read more...
Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A chest Xray and then CT scan revealed complete collapse of her right lower lobe and middle lobes. Mucous retention is seen just proximal to the abrupt read more... October 2016, January 2017
October 2016, January 2017 Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A chest Xray and then CT scan revealed complete collapse of her right lower lobe and middle lobes. Mucous retention is seen just proximal to the abrupt read more...

A bronchoscopy found large amounts of mucous that was suctioned and removed. Aspergillus was found in the mucous on microscopy and A. fumigatus grown in culture. 

She felt better immediately and a follow up scan shows re-expansion of the right middle and lower lobes. 

A diagnosis of Aspergillus bronchitis was made based on the bronchoscopy findings, microscopy and culture results and supported by an positive Aspergillus IgG of 97mg/L (ImmunoCap). 

Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis) Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles.
Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles. Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis)
Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.Courtesy of Dr D Denning, Wythenshawe Hospital, read more... Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later.
Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later. Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.Courtesy of Dr D Denning, Wythenshawe Hospital, read more...
Cresemba Cresemba (Isavuconazole)
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus

Aspergillus spores are incredibly tiny, tough fungal seeds that germinate to form the germ tube and later hyphae. Germination is affected by temperature, humidity and pH among other factors.

About 3-4% of the population, including many asthma sufferers, are allergic to the proteins coating the surface of fungal spores. Levels of spores from most species peak during June-Sep, but aspergillus also peaks in Jan-Feb.

We all inhale hundreds of Aspergillus spores every day, but in healthy people they are cleared by white blood cells that engulf them before they have the chance to germinate. Stopping them from germinating is one potential way of preventing disease.

This picture shows a scanning electron micrograph of germinating Aspergillus fumigatus spores (provided by KM Lord and ND Read). In this picture the spores are clustered in the middle, with the germ tubes radiating outwards.

Read more and view the current spore level report

Aspergillus niger Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation. A niger conidial head TEM in vitro, A niger mature conidium TEM in vitro
A niger conidial head TEM in vitro, A niger mature conidium TEM in vitro Aspergillus niger Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.

Pages