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Skin lesions in patient with acute myeloid leukemia Images and abstract taken from Mert D et.al., Hematol Rep. 2017 Jun 1;9(2):6997. doi: 10.4081/hr.2017.6997. Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.Invasive read more... Zosteriform scatris on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Bullous lesions on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Zosteriform scatris with erythematous halo on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Histological findings of invasive cutaneous aspergillosis. Skin biopsy showing fungal hyphae accumulated in the dermiş., Non-branching fungal hyphae and intensive neutrophil infiltration in the dermis. Fungal infiltration also seemed to invade the vessels.
Zosteriform scatris on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Bullous lesions on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Zosteriform scatris with erythematous halo on the skin of the patient with acute myelogenous leukemia during the febrile neutropenia attack., Histological findings of invasive cutaneous aspergillosis. Skin biopsy showing fungal hyphae accumulated in the dermiş., Non-branching fungal hyphae and intensive neutrophil infiltration in the dermis. Fungal infiltration also seemed to invade the vessels. Skin lesions in patient with acute myeloid leukemia Images and abstract taken from Mert D et.al., Hematol Rep. 2017 Jun 1;9(2):6997. doi: 10.4081/hr.2017.6997. Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.Invasive read more...
AR-12 For further details go to the new antifungal drugs section AR-12 (Antitumor/Antifungal Celecoxib Derivative)
AR-12 (Antitumor/Antifungal Celecoxib Derivative) AR-12 For further details go to the new antifungal drugs section
Tipifarnib Farnesyltransferase inhibitor - see new Antifungal drugs section for more details Tipifarnib (farnesyltransferase inhibitor)
Tipifarnib (farnesyltransferase inhibitor) Tipifarnib Farnesyltransferase inhibitor - see new Antifungal drugs section for more details
Manumycin A Farnesyltransferase inhibitor - see New Antifungal drugs section for more details Manumycin A (farnesyltransferase inhibitor)
Manumycin A (farnesyltransferase inhibitor) Manumycin A Farnesyltransferase inhibitor - see New Antifungal drugs section for more details
Case 66: Aspergillus invasive skin graft infection in a child suffering from severe burns. Figure 1. Case history number 66
Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A chest Xray and then CT scan revealed complete collapse of her right lower lobe and middle lobes. Mucous retention is seen just proximal to the abrupt read more... October 2016, January 2017
October 2016, January 2017 Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A chest Xray and then CT scan revealed complete collapse of her right lower lobe and middle lobes. Mucous retention is seen just proximal to the abrupt read more...

A bronchoscopy found large amounts of mucous that was suctioned and removed. Aspergillus was found in the mucous on microscopy and A. fumigatus grown in culture. 

She felt better immediately and a follow up scan shows re-expansion of the right middle and lower lobes. 

A diagnosis of Aspergillus bronchitis was made based on the bronchoscopy findings, microscopy and culture results and supported by an positive Aspergillus IgG of 97mg/L (ImmunoCap). 

Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis) Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles.
Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles. Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis)
Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.Courtesy of Dr D Denning, Wythenshawe Hospital, read more... Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later.
Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later. Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.Courtesy of Dr D Denning, Wythenshawe Hospital, read more...
Cresemba Cresemba (Isavuconazole)
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus

Aspergillus spores are incredibly tiny, tough fungal seeds that germinate to form the germ tube and later hyphae. Germination is affected by temperature, humidity and pH among other factors.

About 3-4% of the population, including many asthma sufferers, are allergic to the proteins coating the surface of fungal spores. Levels of spores from most species peak during June-Sep, but aspergillus also peaks in Jan-Feb.

We all inhale hundreds of Aspergillus spores every day, but in healthy people they are cleared by white blood cells that engulf them before they have the chance to germinate. Stopping them from germinating is one potential way of preventing disease.

This picture shows a scanning electron micrograph of germinating Aspergillus fumigatus spores (provided by KM Lord and ND Read). In this picture the spores are clustered in the middle, with the germ tubes radiating outwards.

Read more and view the current spore level report

Haemofungin
E1210 structure
E1210 structure

Original article http://www.aspergillus.org.uk/content/vitro-activity-e1210-novel-antifungal-against-clinically-important-yeasts-and-molds

Patient JSG: Nicotine stained fingers in ABPA with bronchiectasis Patient with chronic productive cough, chest pain and ABPA, unable to take itraconazole or nebulised amphotericin B. Smokes at least 40 roll up cigarettes a day. Nicotine stained fingers - image 1, Nicotine stained fingers - image 2
Nicotine stained fingers - image 1, Nicotine stained fingers - image 2 Patient JSG: Nicotine stained fingers in ABPA with bronchiectasis Patient with chronic productive cough, chest pain and ABPA, unable to take itraconazole or nebulised amphotericin B. Smokes at least 40 roll up cigarettes a day.
T-2307 The chemical structure of the novel arylamidine T-2307
T-2307 The chemical structure of the novel arylamidine T-2307
Laryngeal Aspergillosis, ptSA Laryngeal aspergillosis, probably related to inhaled corticosteroids. Image A., Image B., Image C., Image D.
Image A., Image B., Image C., Image D. Laryngeal Aspergillosis, ptSA Laryngeal aspergillosis, probably related to inhaled corticosteroids.

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