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Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A October 2016, January 2017
October 2016, January 2017 Aspergillus bronchitis and mucoid impaction: PtMK MK is 59 years old and presented with right sided pleuritic chest pain and coughing over 1 week. A

A bronchoscopy found large amounts of mucous that was suctioned and removed. Aspergillus was found in the mucous on microscopy and A. fumigatus grown in culture. 

She felt better immediately and a follow up scan shows re-expansion of the right middle and lower lobes. 

A diagnosis of Aspergillus bronchitis was made based on the bronchoscopy findings, microscopy and culture results and supported by an positive Aspergillus IgG of 97mg/L (ImmunoCap). 

Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis) Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles.
Image A: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image B: Red skin rash on arms due to effect of inhaled steroids termed ecchymosis., Image C: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles., Image D: Papular rash with blisters on the back, associated with CPA but prior to treatment, rash appeared 2 years previously in October 2007. The rash resolved on treatment with azoles. Papular rash with CPA Drug rashes: Drug interactions between steroids and anti-fungal drugs - (ecchymosis)
Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later.
Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Voriconazole rash. Following 8 weeks of Voriconazole, patient had remarkable facial erythema, most consistent with sun exposure because of sparing of her neck., Patient AB: Discoid lupus erythematosus following 12 months voriconazole therapy. This improved with use of sunblock factor 30 and resolved after discontinuation of voriconazole, 2 months later. Facial erythema: Side effects of anti-fungal drugs - drug rashes Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole
Cresemba Cresemba (Isavuconazole)
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus
Germinating spores of Aspergillus fumigatus Germinating spores of Aspergillus fumigatus

Scanning Electron Micrograph of germinating Aspergillus fumigatus spores (provided by KM Lord and ND Read)

Sputum plug Fungal plug Fungal plug
Fungal plug Sputum plug Fungal plug

Fungal plug, Image sent in by ptPC-W. Patient female aged 70 years, Image taken on 3/12/2014

Haemofungin
E1210 structure
Nicotine stained fingers Patient: JSG Nicotine stained fingers in ABPA with bronchiectasis Nicotine stained fingers - image 1, Nicotine stained fingers - image 2
Nicotine stained fingers - image 1, Nicotine stained fingers - image 2 Nicotine stained fingers Patient: JSG Nicotine stained fingers in ABPA with bronchiectasis

Patient with chronic productive cough, chest pain and ABPA, unable to take itraconazole or nebulised amphotericin B. Smokes at least 40 roll up cigarettes a day.

T-2307 The chemical structure of the novel arylamidine T-2307 T-2307
T-2307 T-2307 The chemical structure of the novel arylamidine T-2307
VL-2397 (ASP2397) VL-2397 (formerly known as ASP2397) is a novel antifungal drug initially developed by our partner, VL-2397 (ASP2397)
VL-2397 (ASP2397) VL-2397 (ASP2397) VL-2397 (formerly known as ASP2397) is a novel antifungal drug initially developed by our partner,
SCY-078 (MK-3118) SCY-078, new orally available beta-1,3-d-glucan synthase inhibitor, Formely MK-3118. SCY-078, new orally available beta-1,3-d-glucan synthase inhibitor
SCY-078, new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 (MK-3118) SCY-078, new orally available beta-1,3-d-glucan synthase inhibitor, Formely MK-3118.
Biafungin acetate Biafungin acetate, a new echinocandin Biafungin acetate, a new echinocandin
Biafungin acetate, a new echinocandin Biafungin acetate Biafungin acetate, a new echinocandin
Primary Aspergillus pneumonia Pt DSM Community acquired primary Aspergillus pneumonia. Two x-rays taken on 02/02/2010 then Pt DSM Community acquired primary Aspergillus pneumonia 05/03/2010, Pt DSM, Community acquired Aspergillus pneumonia 02/02/2010
Pt DSM Community acquired primary Aspergillus pneumonia 05/03/2010, Pt DSM, Community acquired Aspergillus pneumonia 02/02/2010 Primary Aspergillus pneumonia Pt DSM Community acquired primary Aspergillus pneumonia. Two x-rays taken on 02/02/2010 then
Community acquired Aspergillus pneumonia July 2011 primary Aspergillus pneumonia (Pt LG) July 2011 primary asp pneumonia
July 2011 primary asp pneumonia Community acquired Aspergillus pneumonia July 2011 primary Aspergillus pneumonia (Pt LG)

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