Editorial Board

Staff of the Aspergillus laboratory (1.1998)
Five scientists (A. Beauvais, C. d'Enfert, T. Fontaine, O. Ibrahim- Granet, S. Paris); three research assistants (J.P. Debeaupuis, M. Diaquin, J. Sarfati); four post doctoral fellows (C. Dubreucq, T. Magnien, P. Mol, I. Mouyna)
Interests of the laboratory: mainly research Clinical interest: A. fumigatus infections in immunocompetent and immunosuppressed patients.

Research interests: Pathogenesis of invasive aspergillosis: construction of mutants tested in a mouse model of IA; killing by phagocytes (just starting)
Molecular epidemiology and diagnosis (antigen characterisation) of aspergillosis
Morphogenesis: study of enzymes involved in conidial germination and cell wall construction
Techniques used: Biochemistry, Molecular biology, Cell biology, Immunochemistry

Key contributions to the recent literature:

• Bart-Delabesse E., Sarfati J., Debeaupuis J.P., van Leeuwen W., van Belkum A., Bretagne S., Latgé J.P. Comparison of restriction fragment length polymorphism, microsatellite length polymorphism, and random amplification of polymorphic DNA analyses for fingerprinting Aspergillus fumigatus isolates. Journal of Clinical Microbiology 2001 Jul;39(7):2683-6.
• Latgé J.P. The pathobiology of Aspergillus fumigatus. Trends in Microbiology 2001 Aug;9(8):382-9.
• Bernard M., Latgé J.P. Aspergillus fumigatus cell wall: composition and biosynthesis. Medical Mycology 2001;39 Suppl 1:9-17.
• Bernard M., Mouyna I., Dubreucq G., Debeaupuis J.P., Fontaine T., Vorgias C., Fuglsang C., Latgé J.P. Characterization of a cell-wall acid phosphatase (PhoAp) in Aspergillus fumigatus. Microbiology 2002 Sep;148(Pt 9):2819-29.
• Hebart H., Bollinger C., Fisch P., Sarfati J., Meisner C., Baur M., Loeffler J., Monod M., Latgé J.P., Einsele H. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 2002 Dec 15;100(13):4521-8. Epub 2002 Aug 01.
• Ibrahim-Granet O., Philippe B., Boleti H., Boisvieux-Ulrich E., Grenet D., Stern M., Latgé J.P. Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages. Infection and Immunity 2003 Feb;71(2):891-903.
• Fontaine T., Magnin T., Melhert A., Lamont D., Latgé J.P., Ferguson M.A. Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins. Glycobiology 2003 Mar;13(3):169-77.
• Philippe B., Ibrahim-Granet O., Prevost M.C., Gougerot-Pocidalo M.A., Sanchez Perez M., Van der Meeren A., Latgé J.P. Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infection and Immunity 2003 Jun;71(6):3034-42.
• Paris S., Wysong D., Debeaupuis J.P., Shibuya K., Philippe B., Diamond R.D., Latgé J.P. Catalases of Aspergillus fumigatus. Infection and Immunity 2003 Jun;71(6):3551-62.
• Paris S, Wysong D, Debeaupuis JP, Shibuya K, Philippe B, Diamond RD, Latge JP. Catalases of Aspergillus fumigatus. Infect Immun. 2003 Jun;71(6):3551-62.
• Braedel S, Radsak M, Einsele H, Latge JP, Michan A, Loeffler J, Haddad Z, Grigoleit U, Schild H, Hebart H. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol. 2004 May;125(3):392-9.
• Mouyna I, Henry C, Doering TL, Latge JP. Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus. FEMS Microbiol Lett. 2004 Aug 15;237(2):317-24.
• Fontaine T, Smith TK, Crossman A, Brimacombe JS, Latge JP, Ferguson MA. In vitro biosynthesis of glycosylphosphatidylinositol in Aspergillus fumigatus. Biochemistry. 2004 Dec 7;43(48):15267-75.
• Carotti C, Ragni E, Palomares O, Fontaine T, Tedeschi G, Rodriguez R, Latge JP, Vai M, Popolo L. Characterization of recombinant forms of the yeast Gas1 protein and identification of residues essential for glucanosyltransferase activity and folding. Eur J Biochem. 2004 Sep;271(18):3635-45.
• Balloy V, Huerre M, Latge JP, Chignard M. Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun. 2005 Jan;73(1):494-503.
• Beauvais A, Latge JP. Chitinases and peptide mimotopes. Chem Biol. 2005 Jan;12(1):7-8. Review.
• Beauvais A, Maubon D, Park S, Morelle W, Tanguy M, Huerre M, Perlin DS, Latge JP. Two alpha(1-3) glucan synthases with different functions in Aspergillus fumigatus. Appl Environ Microbiol. 2005 Mar;71(3):1531-8.
• Mouyna I, Morelle W, Vai M, Monod M, Lechenne B, Fontaine T, Beauvais A, Sarfati J, Prevost MC, Henry C, Latge JP. Deletion of GEL2 encoding for a beta(1-3)glucanosyltransferase affects morphogenesis and virulence in Aspergillus fumigatus. Mol Microbiol. 2005 Jun;56(6):1675-88.
• Morelle W, Bernard M, Debeaupuis JP, Buitrago M, Tabouret M, Latge JP. Galactomannoproteins of Aspergillus fumigatus. Eukaryot Cell. 2005 Jul;4(7):1308-16.
• Paoletti M, Rydholm C, Schwier EU, Anderson MJ, Szakacs G, Lutzoni F, Debeaupuis JP, Latge JP, Denning DW, Dyer PS. Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol. 2005 Jul 12;15(13):1242-8.
• Tekaia F, Latge JP. Aspergillus fumigatus: saprophyte or pathogen? Curr Opin Microbiol. 2005 Aug;8(4):385-92. Review.
• Latge JP, Mouyna I, Tekaia F, Beauvais A, Debeaupuis JP, Nierman W. Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus. Med Mycol. 2005 May;43 Suppl 1:S15-22. Review.
• Balloy V, Si-Tahar M, Takeuchi O, Philippe B, Nahori MA, Tanguy M, Huerre M, Akira S, Latge JP, Chignard M. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect Immun. 2005 Sep;73(9):5420-5.
• Costachel C, Coddeville B, Latge JP, Fontaine T. Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus. J Biol Chem. 2005 Dec 2;280(48):39835-42.
• Pringle A, Baker DM, Platt JL, Wares JP, Latge JP, Taylor JW. Cryptic speciation in the cosmopolitan and clonal human pathogenic fungus Aspergillus fumigatus. Evolution Int J Org Evolution. 2005 Sep;59(9):1886-99.
• Beck O, Topp MS, Koehl U, Roilides E, Simitsopoulou M, Hanisch M, Sarfati J, Latge JP, Klingebiel T, Einsele H, Lehrnbecher T. Generation of highly-purified and functionally active human TH1-cells against aspergillus fumigatus. Blood. 2005 Dec 1
• Berkova N, Lair-Fulleringer S, Femenia F, Huet D, Wagner MC, Gorna K, Tournier F, Ibrahim-Granet O, Guillot J, Chermette R, Boireau P, Latge JP. Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells. Int Immunol. 2005 Dec 15;

Contacts:
Aspergillus Laboratory,
Pasteur Institute,
28 rue du Dr. Roux,
75724 Paris Cedex 15,
France.

Telephone - +33 1 40 61 35 18
FAX - +33 1 40 61 34 19
E-mail jplatge@pasteur.fr