Clinical Information Architect

Jenny Bartholomew BSc PhD

Graduated in 1978 from Manchester University with a BSc (Hons) in Biochemistry . I continued my postgraduate studies at Manchester Medical School studying changes in connective tissue in Atherosclerosis. I graduated with my PhD in 1981 and spent the next four years as a Lecturer and Postgraduate Fellow, at Monash University, Melbourne, Australia - where my research focussed on connective tissue damage in Rheumatoid Arthritis where we first demonstrated the presence of TNF alpha in inflamed cartilage, using a model RA system. In 1986 I returned to Britain where I continued research into Rheumatoid Arthritis at Withington Hospital, Manchester.

1989-1997 I accepted a Postdoctoral position in the Department of Immunology at the Paterson Institute for Cancer Research, Christie Hospital, Manchester. My research interests included the regulation of HLA class I expression in cervical carcinomas and the relevance of HPV oncoproteins in cervical cancer. In 1994 I became an Honorary University Teacher.

During a short career break I studied Web Design, Dreamweaver, Photoshop and microcomputing, completing my studies in June 2001. I have been designing, editing and writing for the Aspergillus website from 2001 to the present, providing clinical information for patients, scientists and clinicians. I also manage and write for the National Aspergillosis Centre, Mycology Reference Laboratory and Fungal Research Trust.

Some of my Publications:

• Bartholomew, J S, J M Evanson and DE Woolley . Rheumatol. Int., II: 37-40, 1991 Serum IgE Anti-cartilage Collagen Antibodies in Rheumatoid Patients.
• Bartholomew,J S,J M Evanson and DE Woolley . Allergy Digests, 2: 30-31, 1992 Collagen Specific IgE Antibodies in Rheumatoid Patients.
• Stacey,S N, J S Bartholomew, A Ghosh, P L Stern, M Mackett and J R Arrand. J.Gen. Vir., 73: 2337-2345, 1992 Expression of human papillomavirus type 16 E6 protein by recombinant baculovirus and use for detection of anti-E6 antibodies in human sera.
• Stacey,S N, A Ghosh, J S Bartholomew, R W Tindle, P L Stern, M Mackett and J R Arrand. J. Med. Virol., 40: 14-21, 1993. Expression of human papillomavirus type 16 E7 protein by recombinant baculovirus and use for the detection of E7 antibodies in sera from cervical carcinogen patients.
• Bartholomew,JS, S N Stacey, B Coles, D Burt, I R Arrand and P L Stern. European Journal of Immunology, 24: 3175-3179, 1994 Identification of a naturally processed HLA-A0201 restricted viral peptide from cells expressing human papillomavirus type 16 E6 oncoprotein.
• Bartholomew J and P L Stern.
  In: Modulation of MHC Antigen Expression and Disease. Eds E G Blair, D J Maudsley and C P Pringle, 233-250, 1994 MHC expression in HPV associated cervical cancer.
• Ellis JRM, P I Keating, J Baird, E F Hounsell, D V Renouf, M Rowe, D Hopkins, M F Duggan-Keen, J.S Bartholomew, L S Young and P L Stern. Nature Medicine, 1,464-470, 1995 An HP V 16 variant is associated with cervical carcinoma in HLA-B7 positive women.
• Bartholomew,JS, S. Glenville, S. Sarkar, D.I. Burt, M.A. Stanley, F. Ruiz-Cabens, J. Chengang, F. Garrido and P .L. Stern. Cancer Res. March 1, 1997. Integration of high-risk human papillomavirus DNA is linked to the down-regulation of Class I Human leukocyte antigens by steroid hormones in cervical tumour cells.
• Brady CS. Bartholomew JS. Burt DJ. Duggan-Keen MF. Glenville S. Telford N. Little AM. Davidson JA. Jimenez P. Ruiz-Cabello F. Garrido F. Stern PL.
  Tissue Antigens. 55(5):401-11, 2000 May. Multiple mechanisms underlie HLA dysregulation in cervical cancer.
• Fungi: friends or foes? Biological Sciences Review 17(1) 24-28, 2004
• Mabey Gilsenan JE, Atherton G, Bartholomew J, Giles PF, Attwood TK, Denning DW, Bowyer P.
  Aspergillus genomes and the aspergillus cloud Nucleic Acids Res. 2009 Jan;37(Database issue):D509-14. Epub 2008 Nov 27

E-mail: jennifer.bartholomew@manchester.ac.uk