Editorial Board

Professor of Medicine and Medical Mycology and Consultant in Infectious Diseases and Mycology, Wythenshawe Hospital and University of Manchester.

Graduate of Guy's Hospital, University of London, 1980. Clinical training in internal medicine, infectious diseases, microbiology, paediatrics and haematology in London, Glasgow and California (1980-1990). Research training at the MRC Clinical Research Centre, Harrow, UK (1985-87) and Stanford University, California, USA (1987-1990). Granted a personal chair by Manchester University in 2005.

My clinical interests are in fungal diseases, immunocompromised patients and complex hospital infection problems.

My research interests relate to antifungal susceptibility testing and resistance, pathogenesis of invasive aspergillosis, clinical studies of new antifungal agents and Aspergillus genomics.

In addition to continuing clinical practice and research, I was instrumental in starting a biotechnology company called F2G. F2G has identified several new promising antifungal drug candidates , one of which is shortly to be studied in human volunteers. Currently I chair F2G's Scientific Advisory Board and act as a consultant to it.

In 2006, I founded Myconostica, a molecular diagnostics spin-out of The University of Manchester. Myconostica developed and commercialised rapid real-time molecular diagnostic tests for Aspergillus and Pneumocystis, before being acquired by Lab21 in May 2011. I advise Lab21 on clinical aspects of fungal diagnosis as a consultant.

Key contributions to the literature:

• Denning DW, Clemons KV, Hanson LH, Stevens DA. Restriction endonuclase analysis of total cellular DNA of Aspergillus fumigatus isolates of geographically and epidemiologically diverse origin. J Infect Dis 1990; 162: 1151-1158.
• Denning DW, Stevens DA. Antifungal and surgical treatment of invasive aspergillosis: review of 2121 published cases. Rev Infect Dis 1990; 12: 1147-1201.
• Denning DW, Follansbee S, Scolaro M, Norris S, Edelstein D, Stevens DA. Pulmonary aspergillosis in AIDS. N Engl J Med 1991; 324: 654-662.
• Birch M, Robson G, Law D, Denning DW. Evidence of multiple phospholipase activities of Aspergillus fumigatus. Infect Immun 1996;64:751-755.
• Denning DW, Venkateswarlu K, Oakley K, Anderson MJ, Manning NJ, Stevens DA, Warnock DW, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrob Ag Chemother 1997; 41: 1364-1368.
• Verweij PE, Denning DW. The challenge of invasive aspergillosis: Increasing numbers in diverse patient groups. Int J Infect Dis 1997;2:61-63.
• Denning DW. Invasive aspergillosis. Clin Infect Dis 1998;26:781-805.
• Stevens DA, Kan VL, Judson MA, Morrison VA, Dummer S, Denning DW, Bennett JE, Walsh TJ, Patterson TF, Pankey GA. Practice guidelines for diseases caused by Aspergillus. Clin Infect Dis 2000; 30: 6696-709
• Brookman JL, Denning DW. Molecular genetics in Aspergillus fumigatus. Curr Op Microbiol 2000;3:468-474.
• Moore CB, Sayers N, Mosquero J, Slaven J, Denning DW. Antifungal drug resistance in Aspergillus. J Infection 2000;41:203-220.
• Crosdale D, Poulton K, Ollier W, Thomson W, Denning DW. Mannose binding lectin gene polymorphisms as a susceptibility factor for chronic necrotising pulmonary aspergillosis. J Infect Dis 2001;184:653-6.
• Ascioglu S, Rex JH, de Pauw B,, Bennett JE, Bille J, Crokaert F, Denning DW, Donnelly JP, Edwards JE, Erjavec Z, Fiere D, Lortholary O, Maertens J, Meis JF, Patterson T, Ritter J, Selleslag D, Stevens DA, Walsh TJ. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer: An international consensus. Clin Infect Dis 2002:34:7-14.
• Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern W, Marr KA, Ribaud P, Lortholary O,Sylvester R, de Pauw B, Rubin RH, Wingard JR, Stark PS, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF. Randomised comparison of voriconazole and amphotericin B in primary therapy of invasive aspergillosis. N Engl J Med 2002;347:408-15.
• Denning DW, Riniotis K, Dobrashian R, Sambatakou H. Chronic cavitary and fibrosing pulmonary and pleural aspergillosis: Case series, proposed nomenclature and review. Clin Infect Dis 2003;37 (Suppl 3):S265-80.
• Pain A, Woodward J, Quail MA, Anderson MJ, Clark R, Collins M, Fosker N, Fraser A, Harris D, Larke N, Murphy L, Humphray S, O'Neil S, Pertea M, Price C, Rabbinowitsch E, Rajandream MA, Salzberg S, Saunders D, Seeger K, Sharp S, Warren T, Denning DW, Barrell B, Hall N. An insight into the genome of the most abundant opportunist human pathogen: analysis of 922 kb fragment of chromosome VIII of Aspergillus fumigatus. Fung Genet Biol 2004;41:443-53.
• Hope WW, Denning DW. Optimising antifungal therapy for individual patients. Intern Med J. 2004 Apr;34(4):147-9.
• Hope WW, Padwell A, Guiver M, Denning DW. Invasive pulmonary aspergillosis with spontaneous resolution and the diagnostic utility of PCR from tissue specimens. J Infect. 2004 Aug;49(2):136-40.
• Zaspel U, Denning DW, Lemke AJ, Greene R, Schurmann D, Maschmeyer G, Ruhnke M, Herbrecht R, Ribaud P, Lortholary O, Zonderland H, Rabe KF, Rottgen R, Bittner R, Neumann K, Oestmann JW. Diagnosis of IPA in HIV: the role of the chest X-ray and radiologist. Eur Radiol. 2004 Nov;14(11):2030-7.
• Denning DW. Related Articles, Links Aspergillosis in "nonimmunocompromised" critically ill patients. Am J Respir Crit Care Med. 2004 Sep 15;170(6):580-1.
• Boyd AE, Modi S, Howard SJ, Moore CB, Keevil BG, Denning DW. Adverse reactions to voriconazole. Clin Infect Dis. 2004 Oct 15;39(8):1241-4.
• Maertens J, Raad I, Petrikkos G, Boogaerts M, Selleslag D, Petersen FB, Sable CA, Kartsonis NA, Ngai A, Taylor A, Patterson TF, Denning DW, Walsh TJ; Caspofungin Salvage Aspergillosis Study Group. Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis. 2004 Dec 1;39(11):1563-71.
• O'Driscoll BR, Hopkinson LC, Denning DW. Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med. 2005 Feb 18;5(1):4.
• Paoletti M, Rydholm C, Schwier EU, Anderson MJ, Szakacs G, Lutzoni F, Debeaupuis JP, Latge JP, Denning DW, Dyer PS. Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol. 2005 Jul 12;15(13):1242-8.
• Warn PA, Sharp A, Denning DW. In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp. J Antimicrob Chemother. 2005 Nov 10;
• Patterson TF, Boucher HW, Herbrecht R, Denning DW, Lortholary O, Ribaud P, Rubin RH, Wingard JR, DePauw B, Schlamm HT, Troke P, Bennett JE; European Organization for Research and Treatment of Cancer (EORTC) Invasive Fungal Infections Group (IFIG); Pfizer Global Aspergillus Study Group. Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcome. Clin Infect Dis. 2005 Nov 15;41(10):1448-52.
• Hope WW, Walsh TJ, Denning DW. Laboratory diagnosis of invasive aspergillosis. Lancet Infect Dis. 2005 Oct;5(10):609-22. Review.
• Paisley D, Robson GD, Denning DW. Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus. Med Mycol. 2005 Aug;43(5):397-401.
• Sambatakou H, Denning DW. Invasive pulmonary aspergillosis transformed into fatal mucous impaction by immune reconstitution in an AIDS patient. Eur J Clin Microbiol Infect Dis. 2005 Sep;24(9):628-33.
• Hope WW, Walsh TJ, Denning DW. Related Articles, Links The invasive and saprophytic syndromes due to Aspergillus spp. Med Mycol. 2005 May;43 Suppl 1:S207-38. Review.
• Nierman WC, May G, Kim HS, Anderson MJ, Chen D, Denning DW. What the Aspergillus genomes have told us. Med Mycol. 2005 May;43 Suppl 1:S3-5. Review.

Contact:

David W. Denning FRCP FRCPath FIDSA FMedSci
Professor of Medicine and Medical Mycology 
Director, National Aspergillosis Centre
Education and Research Centre
University Hospital of South Manchester (Wythenshawe Hospital)
Southmoor Road
Manchester M23 9LT UK

www.nationalaspergillosiscentre.org.uk 
www.mycologymanchester.org 
www.aspergillus.org.uk 
www.cadre-genomes.org.uk

E-mail Ddenning@manchester.ac.uk